Nuclear factor-κB and STAT3 are constitutively active in CD138 + cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis

Alok C. Bharti; Shishir Shishodia; James M. Reuben; Donna Weber; Raymond Alexanian; Saroj Raj-Vadhan; Zeev Estrov; Moshe Talpaz; Bharat B. Aggarwal

doi:10.1182/blood-2003-06-2151

Nuclear factor-κB and STAT3 are constitutively active in CD138 ⁺ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis

Alok C. Bharti, Shishir Shishodia, James M. Reuben, Donna Weber, Raymond Alexanian, Saroj Raj-Vadhan, Zeev Estrov, Moshe Talpaz, Bharat B. Aggarwal

University of Texas MD Anderson Cancer Center

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	3175-3184
Number of pages	10
Journal	Blood
Volume	103
Issue number	8
DOIs	https://doi.org/10.1182/blood-2003-06-2151
State	Published - Apr 15 2004
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Immunology
Hematology
Cell Biology

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10.1182/blood-2003-06-2151

Cite this

Bharti, A. C., Shishodia, S., Reuben, J. M., Weber, D., Alexanian, R., Raj-Vadhan, S., Estrov, Z., Talpaz, M., & Aggarwal, B. B. (2004). Nuclear factor-κB and STAT3 are constitutively active in CD138 ⁺ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. Blood, 103(8), 3175-3184. https://doi.org/10.1182/blood-2003-06-2151

Bharti, AC, Shishodia, S, Reuben, JM, Weber, D, Alexanian, R, Raj-Vadhan, S, Estrov, Z, Talpaz, M & Aggarwal, BB 2004, 'Nuclear factor-κB and STAT3 are constitutively active in CD138 ⁺ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis', Blood, vol. 103, no. 8, pp. 3175-3184. https://doi.org/10.1182/blood-2003-06-2151

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AU - Bharti, Alok C.

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AU - Reuben, James M.

AU - Weber, Donna

AU - Alexanian, Raymond

AU - Raj-Vadhan, Saroj

AU - Estrov, Zeev

AU - Talpaz, Moshe

AU - Aggarwal, Bharat B.

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Nuclear factor-κB and STAT3 are constitutively active in CD138 + cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis

ASJC Scopus Subject Areas

Access to Document

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Nuclear factor-κB and STAT3 are constitutively active in CD138 ⁺ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis