Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC-MS/MS method: Application to an oral bioavailability study of genistein in mice

Zhen Yang; Wei Zhu; Song Gao; Haiyan Xu; Baojian Wu; Kaustubh Kulkarni; Rashim Singh; Lan Tang; Ming Hu

doi:10.1016/j.jpba.2010.03.011

Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC-MS/MS method: Application to an oral bioavailability study of genistein in mice

Zhen Yang
, Wei Zhu
, Song Gao
, Haiyan Xu
, Baojian Wu
, Kaustubh Kulkarni
, Rashim Singh
, Lan Tang
, Ming Hu

University of Houston

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	81-89
Number of pages	9
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	53
Issue number	1
DOIs	https://doi.org/10.1016/j.jpba.2010.03.011
State	Published - Sep 2010
Externally published	Yes

ASJC Scopus Subject Areas

Analytical Chemistry
Pharmaceutical Science
Drug Discovery
Spectroscopy
Clinical Biochemistry

Keywords

Genistein
Pharmacokinetics
Phase II metabolites
UPLC-MS/MS

Access to Document

10.1016/j.jpba.2010.03.011

Cite this

Yang, Z., Zhu, W., Gao, S., Xu, H., Wu, B., Kulkarni, K., Singh, R., Tang, L., & Hu, M. (2010). Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC-MS/MS method: Application to an oral bioavailability study of genistein in mice. Journal of Pharmaceutical and Biomedical Analysis, 53(1), 81-89. https://doi.org/10.1016/j.jpba.2010.03.011

Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC-MS/MS method: Application to an oral bioavailability study of genistein in mice. / Yang, Zhen; Zhu, Wei; Gao, Song et al.
In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 53, No. 1, 09.2010, p. 81-89.

Research output: Contribution to journal › Article › peer-review

Yang, Z, Zhu, W, Gao, S, Xu, H, Wu, B, Kulkarni, K, Singh, R, Tang, L & Hu, M 2010, 'Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC-MS/MS method: Application to an oral bioavailability study of genistein in mice', Journal of Pharmaceutical and Biomedical Analysis, vol. 53, no. 1, pp. 81-89. https://doi.org/10.1016/j.jpba.2010.03.011

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keywords = "Genistein, Pharmacokinetics, Phase II metabolites, UPLC-MS/MS",

author = "Zhen Yang and Wei Zhu and Song Gao and Haiyan Xu and Baojian Wu and Kaustubh Kulkarni and Rashim Singh and Lan Tang and Ming Hu",

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AU - Zhu, Wei

AU - Gao, Song

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AU - Kulkarni, Kaustubh

AU - Singh, Rashim

AU - Tang, Lan

AU - Hu, Ming

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KW - Phase II metabolites

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Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC-MS/MS method: Application to an oral bioavailability study of genistein in mice

ASJC Scopus Subject Areas

Keywords

Access to Document

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